- Pet/Vet
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by Skippack Pharmacy
What is Tacrolimus and how does it work?
Tacrolimus is a powerful immunosuppressant used in veterinary medicine to treat immune-related eye conditions. It works by inhibiting calcineurin, an enzyme involved in activating T-cells—immune cells that cause inflammation. By suppressing this immune response, Tacrolimus helps protect the eye from ongoing damage and promotes healing, especially in cases where the immune system attacks the tear glands or ocular tissues.
When is Tacrolimus prescribed
Tacrolimus is typically used for pets who have not responded well to Cyclosporine or who have more severe forms of ocular inflammation. It’s especially effective for treating keratoconjunctivitis sicca (KCS), also known as dry eye, as well as other conditions like pannus or immune-mediated conjunctivitis. Because it is stronger than Cyclosporine, Tacrolimus is often chosen for pets with advanced or difficult-to-manage eye diseases.
How is it compounded and administered?
Tacrolimus eye drops are usually compounded in sterile, oil-based formulations that improve the medication’s contact time with the eye. These customized drops are tailored to each pet’s needs, including the correct strength and volume. Most pets receive the drops once or twice daily, depending on the severity of their condition and their veterinarian’s instructions.
Is Tacrolimus safe for pets?
When prescribed and monitored by a veterinarian, Tacrolimus is considered safe and effective. Mild irritation or stinging may occur when the drops are first applied, but these symptoms often subside with continued use. Because Tacrolimus modifies the immune response, it’s important to monitor for any signs of infection or delayed healing, particularly in pets with weakened immune systems or concurrent health issues.
The benefits of sterile compounding
Sterility is essential when preparing Tacrolimus eye drops. Because these medications come in direct contact with the eye, any contamination could lead to infection or further complications. Tacrolimus eye drops can be life-changing for pets suffering from chronic eye inflammation. By reducing immune system overactivity, they not only alleviate symptoms but also help preserve vision and comfort. If your pet has been struggling with dry eye or other immune-related eye conditions, ask your veterinarian if Tacrolimus might be the right solution.
